ABSTRACT
The worldwide pandemic of coronavirus disease-2019 (COVID-19) is a devastating and distressing scenario that highlights humanity's inability to build fast diagnostic tools for emerging infectious diseases. However, the majority of existing approaches have a significant probability of false negatives, leading in patient diag-nostic errors and prolonging therapy. Nanoparticles have shown significant improve-ment and have the potential to be used as a platform for quickly and accurately identifying viral infection. The relevance of nanoparticles is potential platforms for COVID-19 diagnostics was emphasized in this research. In addition, nanomaterials have surface chemistry, which may be beneficial for the bioconjugation of molecules, large surface potential, and a significant amplification impact on signals. Due to various potential benefits, metallic nanomaterials like gold, silver nanoparticles, and carbon-based nanomaterials (carbon nanotube and graphene), nanogels, and photonic crystals are utilized for biosensing applications. In compared to traditional techniques for identifying severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), this study covers the most relevant aspects of nanobiosensor-based diagnostics tech-niques. Additionally, major potential challenges and prospects associated with the advancement of these distinct sensors for SARS-CoV-2 detection are discussed in detail. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.